The fabrication of porous poly(ethylene glycol) (PEG)-d hydrogel scaffolds via 

epoxy-amine crosslinked polymerization was conducted in this research works. PEG was chosen as 

the main component of the hydrogel scaffolds due to their unique characteristic including high 

hydrophilicity, biocompatibility and low toxicity properties. The effects of different solvents 

((water, dimethylsulfoxide (DMSO), triethylene glycol dimethyl ether (TGDME), etc) toward 

physical and mechanical properties of fabricated PEG-d hydrogel scaffolds were investigated to 

identify the suitable solvent for fabrication of porous hydrogel scaffolds. From the results obtained, 

DMSO was selected as the solvent because the produced hydrogels scaffolds possessed the 

optimum physical properties as compared to other solvents. In tissue engineering field, porosity of 

scaffolds play key role for cell attachment, grow and proliferation consequently help in regeneration 

of new tissues. Therefore, in this study the macroporous hydrogel scaffolds were produced via 

introduction of fused salt templates in the range sizes of 100–300 µm (small) and 300–600 µm 

(large) in the fabrication process. Improved interconnectivity of pores was achieved and pores sizes 

obtained were according to the size of salt particles utilized in the template. Modification of the 

scaffolds pore morphology resulted in a reduction in the mechanical properties as we expected.